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JASPER'S BASIC MECHANISMS OF THE EPILEPSIES, FIFTH EDITION
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Program

MONDAY, MARCH 4, 2019
Welcome​

2:00 pm –
REGISTRATION OPEN (Cliff Falls Room)

5:00 pm – 7:00 pm
WELCOME RECEPTION (Cliff Falls Room)

OPENING SESSION OF WORKSHOPS (Cliff Falls Room)

​5:00 pm – 5:05 pm
Welcome and Aims of the Jasper’s Workshops
Jeff Noebels, Massimo Avoli, Mike Rogawski, Antonio Delgado Escueta

5:15 pm – 5:30 pm
Welcome From the Sponsors

Vicky Whittemore

Neuronal Network Pathology
Chair and Discussion Leader: David A. Prince

5:30 pm – 5:50 pm
Historical Introduction: "PDS: The First Basic Mechanism"
Massimo Avoli

5:50 pm – 6:10 pm
The Emergence of Epilepsy Genes as Targets for Treatment
Jeffrey Noebels

6:10 pm – 6:30 pm

Hippocampal Network Alterations in Temporal Lobe Epilepsy: New Views and Challenges
Carolyn Houser

6:30 pm – 6:50 pm
Neuropathological Perspective of Focal Cortical Dysplasias and Generalized Epilepsy
Harvey Sarnat

​DINNER (Cliff Falls Room)

​7:10 pm –
Italian Buffet with Drinks

TUESDAY, MARCH 5, 2019
​
Seizure, Networks & Systems

6:30 am – 8:00 am
BREAKFAST BUFFET (Mountain Room)

8:00 am – 10:20 am
WORKSHOP A – FOCAL SEIZURES (Cliff Falls Room)
Chair and Discussion Leader: Jeanne Paz


8:00 am –8:20 am
Low-Voltage Fast Activity at the Onset of Focal Seizures
Marco de Curtis

8:20 am –8:40 am
High-Frequency Oscillations in Rodent Model of Temporal Lobe Epilepsy
Maxime Levesque

8:40 am – 9:00 am
Dynamics of Spontaneous Seizures in Experimental Models In Vitro and In Vivo
John Jefferys
​9:00 am
Connexins, Pannexins and Epilepsy
Peter Carlen

9:20 am
A Classification of Seizures based on Dynamics
Christophe Bernard

9:40 am
Cytokine-Mediated Inhibition of Astrocyte Gap Junction Coupling as a Cause of Temporal Lobe Epilepsy
Christian Steinhauser

10:00 am
Open Floor Discussion
 
10:20 am
Break: Coffee and Snacks
 
WORKSHOP B — GENERALIZED SEIZURES
Chairs and Discussion Leaders: Marco de Curtis and Christophe Bernard

10:40 am
Cortical PV+ Interneuron Dysfunction in the Pathogenesis of Absence Epilepsy
Atul Maheshwari

11:00 am
Novel Role of the Thalamus in Dravet Syndrome
Jeanne Paz

11:20 am
Open Floor Discussion

11:40 am
The CURE Mission and Research Portfolio
Laura Lubbers

12:00 noon
Everyone on Their Own for Lunch, Afternoon Recreational Activity
 
BREAKOUT PARALLEL SESSIONS ON THE 5TH EDITION OF JASPER'S BME BOOK

3:30 pm
Book Section I: Seizures, Networks, and Systems
Led by M. Avoli, C. Bernard, and M. de Curtis

3:30 pm
Book Section II: Epileptogenesis
Led by A. Vezzani and H. Scharfman

WORKSHOP C — EPILEPTOGENESIS: MODELS AND MECHANISMS
Chair and Discussion Leader: Ray Dingledine

4:30 pm
Artificial Intelligence-Guided Phenotyping in Epilepsy
Ivan Soltesz

4:50 pm
Mossy Cells and Epileptogenesis
Helen Scharfman

5:10 pm
Adenosine for Epilepsy Prevention
Detlev Boison

5:30 pm
TrkB-Shc Signaling Protects Against Hippocampal Injury Following Status Epilepticus
James O. McNamara

5:50 pm
Blood Brain Barrier-Induced Aberrant TGF-β Signaling in Epileptogenesis
Daniela Kaufer

6:10 pm
Initiation of an Epileptogenic Cascade by Focal Neuronal Lesions
Steve Danzer

6:30 pm
Open Floor Discussion
 
POSTER SESSION
7:00 pm
Poster Session and Dinner: Buffet with Drinks
 
WORKSHOP D — EPILEPTOGENESIS BIOMARKERS
Chair and Discussion Leaders: Matthias Koepp and William Theodore

8:30 pm
Microvascular Pathology in Seizures and Epileptogenesis: A Mechanism-Driven Biomarker and New Target for Treatment?
Alon Friedman

8:50 pm
Machine-Learning Approach to Discover Novel Biomarkers of Posttraumatic Epilepsy
Asla Pitkanen

9:10 pm
Cerebrospinal Fluid and Blood Micrornas as Biomarkers of Epilepsy
Michele Simonato

9:30 pm
Open Floor Discussion
 
9:50 pm
Adjourn

WEDNESDAY, MARCH 6, 2019
Genes & Network Development

6:30 am
Breakfast Buffet

WORKSHOP E — GENES AND NETWORK DEVELOPMENT
Chair and Discussion Leader: Jeffrey Noebels

8:00 am
Gene Interactome Analysis to Understand Complex Molecular Traits in Epilepsy
Katja Kobow

8:20 am
Molecular Taxonomy of Epilepsy, a Framework to Target Underlying Disease Biology
Stephanie Dedeurwaerdere

WORKSHOP F — MEMBRANE EXCITABILITY AND SYNAPTIC MECHANISMS
Chair and Discussion Leader: Lori Isom

8:40 am
Voltage-gated Sodium Channel Gene SCN2A and Neurological Diseases
Kazuhiro Yamakawa

9:00 am
Potassium Channel Gain of Function in Epilepsy: an Unresolved Paradox
Anastassios Tzingounis

9:20 am
Mechanisms of CACNA1A-associated Epileptic Encephalopathies: from Gene to Networks
Elsa Rossignol

9:40 am
Break: Coffee and Snacks
 
10:00 am
GABA-A Receptors in Epilepsy: Recent Advances in Genetics, Subtype Pharmacology, Plasticity, Brain Circuitry, and Structure-Function
Richard Olsen

10:20 am
TBD
Patrick Cossette

10:40 am
Open Floor Discussion
 
WORKSHOP G — MIGRATION AND MALFORMATION
Chair and Discussion Leader: Bernard Lakaye

11:00 am
Maf Transcription Factors in the Generation and Function of Cortical Interneurons
John Rubenstein

11:20 am
Neurodevelopmental Origins of Human Focal Cortical Dysplasia
Lakshmi Subramanian

11:40 am
Understanding the Mechanisms of Epilepsy in mTOR-Dependent Cortical Malformation
Angelique Bordey

12:00 noon
Role of Brain Somatic Mutations in Genes of the GATOR1-mTOR Pathway in Focal Cortical Dysplasia
Stephanie Baulac

12:20 pm
Open Floor Discussion
 
12:40 pm
Everyone on Their Own for Lunch, Afternoon Recreational Activity

BREAKOUT PARALLEL SESSIONS ON THE 5TH EDITION OF JASPER'S BASIC MECHANISMS OF THE EPILEPSIES BOOK 

2:30 pm
Book Section III: Genes and Network Development
Led by J. Noebels, A. Delgado-Escueta, and E. Rossignol

WORKSHOP H — TOWARDS A CURE IN PROGRESSIVE MYOCLONIC EPILEPSY
Chair and Discussion Leaders: Antonio V. Delgado-Escueta, Berge Minassian, and Jose M. Serratosa

3:30 pm
Overview of Advances in Progressive Myoclonus Epilepsies Including Intraventricular Cerliponase Alfa for CLN2
Berge Minassian

3:50 pm
Early and Late Treatment with Etformin in Lafora Disease Mice
Jose M. Serratosa

4:10 pm
Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion
Matt Gentry

4:30 pm
Antisense Oligonucleotides in SMA,Lafora Disease and Other Epilepsies
Tamar Grossman

4:50 pm
Progress in Progressive Myoclonus-Epilepsy
Berge Minassian

5:10 pm
Electrographic Features of Nodding Syndrome, a Novel Tau-Associated Epileptic Encephalopathy
Rajarshi Mazumder

5:30 pm
Open Floor Discussion
 
POSTER SESSION
6:00 pm
Poster Session and Dinner: Buffet with Drinks
 
WORKSHOP I — MONOGENIC COMORBIDITIES
Chair and Discussion Leader: Helen Scharfman

8:00 pm
Reduced Synaptic Connectivity and Disrupted Oscillatory Population Dynamics in the Medial Prefrontal Cortex of the CNTNAP2 Mouse Model of Autism
Peyman Golshani

8:20 pm
Network Abnormalities and Interneuron Dysfunction in Alzheimer's Disease
Jorge Palop

8:40 pm
On Measuring and Manipulating Melancholia in Mice with mTLE
Vaishnav Krishnan


9:00 pm
Single Gene Mechanisms for SUDEP Risk
Jeffrey Noebels

9:20 pm
Open Floor Discussion
 
9:40 pm
Adjourn

THURSDAY, MARCH 7, 2019
Molecular Therapeutics of Epilepsy

6:30 am
Breakfast Buffet
 
WORKSHOP J — PREVENTING AND STOPPING SEIZURES
Chair and Discussion Leader: Claude Wasterlain

8:00 am
Overview
Michael Rogawski

8:20 am
Status Epilepticus: Role of Synaptic Potentiation
Jaideep Kapur

8:40 am
GABA Signaling: Pathologies and Therapies
Kevin Staley

9:00 am
Multi-Targeted Drug Combinations for Antiepileptogenesis
Wolfgang Loescher

9:20 am
TBD
Pierandrea Muglia

9:40 am
Open Floor Discussion
 
10:00 am
Break: Coffee and Snacks
 
WORKSHOP K — GENE GUIDED AND TARGETED THERAPIES
Chair and Discussion Leader: Michael Rogawski

10:20 am
Gene Therapy for Refractory Epilepsy
Dimitri Kullman

10:40 am
The Role of Gain- and Loss-of-Function Ionotropic Glutamate Receptor Variants in Epilepsy
Steve Traynelis

11:00 am
Epileptogenic Channelopathies Guide Design of XEN901, a Selective Inhibitor of NaV1.6
Charlie Cohen

11:20 am
KCNQ2-Related Epilepsy: Variant Spectrum and Prospects for Precision Therapy
Ed Cooper

11:40 am
Antisense Oligonucleotides in the Treatment of Rare Monogenic Disease
Paul Goldberg

12:00 Noon
Targeted Augmentation of Nuclear Gene Output (TANGO) in SCN1A Dravet Syndrome
Lori Isom

12:20 pm
Open Floor Discussion
 
12:40 pm
Everyone on Their Own for Lunch
 
WORKSHOP L — NEW MODELS AND THERAPEUTIC STRATEGIES
Chair and Discussion Leader: Michael Rogawski

2:00 pm
Animal Models of Therapy Resistant Epilepsy
H. Steve White

2:20 pm
Anti-Inflammatory Strategies for Disease-Modifications
Annamaria Vezzani

2:40 pm
Treatment of Febrile Status Epilepticus: Past, Present and Future
Tallie Z. Baram

3:00 pm
Mechanisms of Ketogenic Diet Action
Jong Rho

3:20 pm
Prophylaxis of Epileptogenesis: Recalibrating the Excitatory-Inhibitory Synaptic Balance
David A. Prince

3:40 pm
Open Floor Discussion
 
BREAKOUT SESSION ON THE 4TH EDITION OF JASPER'S BASIC MECHANISMS OF THE EPILEPSIES BOOK
4:10 pm
Book Section IV: Epilepsy Therapeutics
Led by M. Rogawski, H. S. White, and W. Löscher
Summary of Breakout Sessions on the 5th Edition of Jasper's BME Book

5:00 pm
Book Section I: Seizures, Networks, and Systems
Presented by M. Avoli
 
Book Section II: Epileptogenesis
Presented by A. Vezzani and H. Scharfman
 
Book Section III: Genes and Developing Networks
Presented by J. Noebels and A. Delgado-Escueta
 
Book Section IV: Epilepsy Therapeutics
Presented by M. Rogawski

7:00 pm
Summation of Workshops and Research Priorities 2020 to 2030
 
8:00 pm
Closing Reception and Dinner

FRIDAY, MARCH 8, 2019
Departure

Morning
Picture

The Jasper's Basic Mechanisms of the Epilepsies workshops, which was held in Yosemite National Park, March 4-8, 2019,  enabled planning for the fifth edition of the textbook to be published in print and electronic form. The book will be hosted online by NCBI Bookshelf of the National Institutes of Health.

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